GPR55

Across TCGA cell cohorts, GPR55 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR55-associated genes across cancer lineages are SERPINA12, IFNG, and PRKAG3. Each is linked with GPR55 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR55-to-partner and partner-to-GPR55 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA12 grouped by GPR55-low versus GPR55-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR55→partner) and Y-score (partner→GPR55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SERPINA12 →	+0.012	+4.614	<.001	.004	3	2
BLOOD_Leukemia	IFNG →	+0.225	+4.152	<.001	.009	3	1
BLOOD_Leukemia	PRKAG3 →	+0.045	+4.551	<.001	.004	3	1
BLOOD_Leukemia	C20orf85 →	+0.023	+4.969	<.001	.003	3	1
BLOOD_Leukemia	MMP20 →	+0.061	+4.705	<.001	.003	3	1
BLOOD_Leukemia	TPD52L3 →	+0.014	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

SERPINA12 by GPR55 expression — PANCREAS

Explore this box plot interactively →