Across TCGA pan-cancer cohorts, GPR52 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated GPR52 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GPR52 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GPR52 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD and UCEC are the cancer types where GPR52 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.172	0.840	<.001	26	view →
UCEC	DFS	Median	II,III,IV	1.000	0.443	.042	10	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: GPR52 tumor-vs-normal RNA expression · all GPR52 data types