Across TCGA patient cohorts, GPR52 mutation is significantly associated with the RNA expression of many other genes, with 254 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR52-associated genes across cancer lineages are GPX4, REEP4, and RNF126. Each is linked with GPR52 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR52-to-partner and partner-to-GPR52 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR52→partner) and Y-score (partner→GPR52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPX4 →	+0.635	+3.513	.002	.002	3	2
UCEC	REEP4 →	+0.561	+3.470	.008	.003	3	2
UCEC	RNF126 →	+0.596	+3.491	.001	.002	3	2
UCEC	CBARP →	+0.816	+3.459	.001	.005	3	2
UCEC	POLR2E →	+0.506	+3.338	.008	.005	3	2
UCEC	CLPP →	+0.624	+3.507	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 254 associations by consensus.

Exploration

GPR52 survival (RNA) · tumor vs normal (RNA) · all GPR52 data types