GPR4

Across TCGA patient cohorts, GPR4 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR4-associated genes across cancer lineages are eEF2, GAPDH, and Notch1. Each is linked with GPR4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR4-to-partner and partner-to-GPR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GPR4-low versus GPR4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR4→partner) and Y-score (partner→GPR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.277	+2.321	.031	.033	3	3
UCEC	GAPDH →	+0.509	+3.584	.008	.002	3	2
UCEC	Notch1 →	+0.134	+1.817	.008	.015	3	2
UCEC	Rictor_pT1135 →	-0.082	-1.807	.026	.025	3	2
UCEC	4E-BP1 →	+0.288	+3.321	.003	.009	3	2
UCEC	C-Raf →	+0.154	+1.807	.002	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

eEF2 by GPR4 expression — UCEC

Explore this box plot interactively →