GPR4

Across TCGA cell cohorts, GPR4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,325 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GPR4-associated GO terms across cancer lineages are Positive regulation of intracellular transport, Cellular response to morphine, and Cellular response to isoquinoline alkaloid. Each is linked with GPR4 in more than 6 cancer types. Because this analysis shows association rather than direction, both GPR4-to-partner and partner-to-GPR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular transport grouped by GPR4-low versus GPR4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR4→partner) and Y-score (partner→GPR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of intracellular transport →	+0.060	+0.328	.002	.005	3	7
SOFT_TISSUE	Cellular response to morphine →	+0.164	+0.852	<.001	.002	3	7
SOFT_TISSUE	Cellular response to isoquinoline alkaloid →	+0.164	+0.852	<.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of intracellular transport →	+0.054	+0.077	<.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.051	+0.089	.003	.003	3	6
UPPER_AERODIGESTIVE_TRACT	Protein localization to vacuole →	+0.059	+0.070	.007	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,325 associations by consensus.

Positive regulation of intracellular transport by GPR4 expression — BONE

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