GPR4

Across TCGA cell cohorts, GPR4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR4-associated genes across cancer lineages are OR10R2, PRORY, and DAZ3. Each is linked with GPR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR4-to-partner and partner-to-GPR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10R2 grouped by GPR4-low versus GPR4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR4→partner) and Y-score (partner→GPR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10R2 →	+1.283	+4.551	.006	.004	3	2
BLOOD_Myeloma	PRORY →	+1.180	+4.807	<.001	.006	3	1
BLOOD_Myeloma	DAZ3 →	+1.563	+4.807	<.001	.006	3	1
LUNG_SCLC	OR5H2 →	+0.037	+4.643	<.001	.004	3	1
LUNG_SCLC	ASIC5 →	+0.056	+4.269	.009	.005	3	1
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR10R2 by GPR4 expression — BLOOD_Leukemia

Explore this box plot interactively →