Across TCGA patient cohorts, GPR39 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR39-associated genes across cancer lineages are PCNA, ATM, and 14-3-3_beta. Each is linked with GPR39 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR39-to-partner and partner-to-GPR39 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR39→partner) and Y-score (partner→GPR39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.192	+2.415	.010	.003	3	3
UCEC	ATM →	-0.498	-2.070	.001	.001	3	3
UCEC	14-3-3_beta →	-0.096	-3.558	.006	.002	3	2
UCEC	eIF4E →	+0.200	+2.598	.006	.005	3	2
UCEC	ERK2 →	+0.154	+1.906	.021	.015	3	2
UCEC	MEK1 →	+0.382	+3.169	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

GPR39 survival (RNA) · tumor vs normal (RNA) · all GPR39 data types