Across TCGA cell cohorts, GPR39 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR39-associated genes across cancer lineages are MAGEB4, RBMY1J, and ZCCHC2. Each is linked with GPR39 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR39-to-partner and partner-to-GPR39 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR39→partner) and Y-score (partner→GPR39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MAGEB4 →	+0.006	+5.643	<.001	.002	3	2
OVARY	RBMY1J →	+0.017	+4.807	<.001	.003	3	2
LARGE_INTESTINE	ZCCHC2 →	+1.004	+3.067	<.001	.009	3	1
LARGE_INTESTINE	CHMP7 →	+0.902	+3.064	.001	.009	3	1
LARGE_INTESTINE	MUCL3 →	+0.266	+3.302	<.001	.008	3	1
LARGE_INTESTINE	PROKR1 →	+0.034	+2.648	.008	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

GPR39 survival (RNA) · tumor vs normal (RNA) · all GPR39 data types