GPR37

Across TCGA patient cohorts, GPR37 mutation is significantly associated with the RNA expression of many other genes, with 2,934 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR37-associated genes across cancer lineages are TIPIN, SKA2, and RPL23AP82. Each is linked with GPR37 in more than 3 cancer types. Because this analysis shows association rather than direction, both GPR37-to-partner and partner-to-GPR37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIPIN grouped by GPR37-low versus GPR37-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR37→partner) and Y-score (partner→GPR37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIPIN →	+0.504	+2.343	<.001	<.001	3	4
UCEC	SKA2 →	+0.517	+2.711	.002	<.001	3	3
UCEC	RPL23AP82 →	+0.469	+2.332	<.001	<.001	3	3
UCEC	CDCA2 →	+0.662	+2.721	<.001	.003	3	3
UCEC	MAK16 →	+0.443	+2.000	.001	.001	3	3
UCEC	C18orf25 →	+0.428	+2.818	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,934 associations by consensus.

TIPIN by GPR37 expression — UCEC

Explore this box plot interactively →