GPR37

Across TCGA patient cohorts, GPR37 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR37-associated genes across cancer lineages are mTOR_pS2448, Src_pY527, and Caspase-7-cleavedD198. Each is linked with GPR37 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR37-to-partner and partner-to-GPR37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by GPR37-low versus GPR37-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR37→partner) and Y-score (partner→GPR37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.115	-1.986	.032	.029	3	2
UCEC	Src_pY527 →	-0.306	-2.321	.048	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.764	+2.827	<.001	.001	3	2
UCEC	4E-BP1 →	+0.255	+2.351	.009	.018	3	2
UCEC	Di-Ras3 →	-0.118	-2.446	.027	.018	3	2
UCEC	14-3-3_beta →	-0.086	-3.558	.018	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

mTOR_pS2448 by GPR37 expression — UCEC

Explore this box plot interactively →