GPR37

Across TCGA cell cohorts, GPR37 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR37-associated genes across cancer lineages are REG3A, C20orf85, and OR7E24. Each is linked with GPR37 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR37-to-partner and partner-to-GPR37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3A grouped by GPR37-low versus GPR37-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR37→partner) and Y-score (partner→GPR37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	REG3A →	+0.049	+3.734	<.001	.006	3	2
BLOOD_Leukemia	C20orf85 →	+0.024	+3.969	<.001	.009	3	2
LUNG_NSCLC_LUAD	OR7E24 →	+0.004	+4.681	<.001	.003	3	1
SKIN	KRTAP1-3 →	+0.020	+4.437	<.001	.004	3	1
BLOOD_Lymphoma	C1orf185 →	+0.046	+3.321	.003	.006	3	1
BLOOD_Leukemia	CST4 →	+0.047	+3.450	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

REG3A by GPR37 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →