GPR34

Across TCGA pan-cancer cohorts, GPR34 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GPR34 data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher GPR34 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GPR34 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, SKCM, and STAD are the cancer types where GPR34 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.610	0.948	<.001	36	view →
SKCM	OS	Median	All	0.327	0.787	<.001	30	view →
STAD	OS	Median	II,III,IV	0.183	0.677	.004	24	view →
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
UCEC	OS	Median	All	0.961	0.659	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GPR34–KIRP (OS)

Open the KIRP breakdown →