GPR34

Across TCGA patient cohorts, GPR34 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR34-associated genes across cancer lineages are ASNS, ATM, and C-Raf. Each is linked with GPR34 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR34-to-partner and partner-to-GPR34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by GPR34-low versus GPR34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR34→partner) and Y-score (partner→GPR34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.505	+2.222	<.001	.010	3	2
UCEC	ATM →	-0.560	-2.169	<.001	.003	3	2
UCEC	C-Raf →	+0.139	+1.906	.009	.015	3	2
UCEC	EGFR_pY1068 →	-0.213	-2.662	.023	<.001	3	1
UCEC	eIF4E →	+0.185	+1.765	.019	.014	3	1
UCEC	INPP4B →	-0.276	-2.700	.023	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ASNS by GPR34 expression — UCEC

Explore this box plot interactively →