Across TCGA pan-cancer cohorts, GPR33 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GPR33 data layer.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GPR33 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GPR33 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.
HNSC, COAD, and LUSC are the cancer types where GPR33 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.