GPR32

Across TCGA pan-cancer cohorts, GPR32 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GPR32 data layer compared with 13 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher GPR32 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GPR32 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

MESO, LUAD, and LUSC are the cancer types where GPR32 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.052	0.567	<.001	36	view →
LUAD	OS	Median	II,III,IV	0.074	0.683	<.001	13	view →
LUSC	OS	Median	All	0.081	0.818	<.001	6	view →
UCEC	DFS	Median	All	1.000	0.625	.033	2	view →
SKCM	DFS	Median	All	1.000	0.623	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GPR32–MESO (OS)

Open the MESO breakdown →