GPR32

Across TCGA cell cohorts, GPR32 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GPR32-associated genes across cancer lineages are NXF5, OPRM1, and COL6A5. Each is linked with GPR32 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR32-to-partner and partner-to-GPR32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXF5 grouped by GPR32-low versus GPR32-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR32→partner) and Y-score (partner→GPR32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NXF5 →	+0.032	+4.467	<.001	.004	3	2
LIVER	OPRM1 →	+0.032	+4.459	<.001	.001	3	1
LIVER	COL6A5 →	+0.012	+4.459	<.001	.001	3	1
LUNG_NSCLC_LUAD	SPATA16 →	+0.024	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	WFDC8 →	+0.014	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	GP9 →	+0.016	+3.362	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

NXF5 by GPR32 expression — LARGE_INTESTINE

Explore this box plot interactively →