GPR3

Across TCGA cell cohorts, GPR3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR3-associated genes across cancer lineages are ASZ1, OR10T2, and OR10R2. Each is linked with GPR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR3-to-partner and partner-to-GPR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASZ1 grouped by GPR3-low versus GPR3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR3→partner) and Y-score (partner→GPR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASZ1 →	+0.132	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OR10T2 →	+0.743	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+1.907	+4.551	<.001	.004	3	1
LARGE_INTESTINE	MSGN1 →	+0.126	+4.930	<.001	.001	3	1
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ASZ1 by GPR3 expression — BLOOD_Leukemia

Explore this box plot interactively →