GPR25

Across TCGA patient cohorts, GPR25 protein abundance is significantly associated with the RNA expression of many other genes, with 461 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GPR25-associated genes across cancer lineages are APOBEC3H, GRAP2, and GSS. Each is linked with GPR25 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR25-to-partner and partner-to-GPR25 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPR25 versus APOBEC3H in LSCC, with a Pearson correlation of 0.94.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR25→partner) and Y-score (partner→GPR25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	APOBEC3H →	+1.070	+0.890	.007	.003	3	1
LSCC	GRAP2 →	+1.061	+0.890	.007	.003	3	1
LSCC	GSS →	-0.814	-0.889	.008	.003	3	1
LSCC	SLC17A9 →	+1.282	+0.890	.002	.003	3	1
LSCC	EMD →	-0.768	-0.889	.003	.003	3	1
LSCC	UBE2I →	-0.687	-0.890	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 461 associations by consensus.

GPR25 vs APOBEC3H — LSCC

Explore this scatter interactively →