GPR22

Across TCGA patient cohorts, GPR22 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR22-associated genes across cancer lineages are EGFR, Ku80, and Notch1. Each is linked with GPR22 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR22-to-partner and partner-to-GPR22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by GPR22-low versus GPR22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR22→partner) and Y-score (partner→GPR22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.241	-3.321	.001	.010	3	1
UCEC	Ku80 →	+0.236	+2.472	.038	.011	3	1
UCEC	Notch1 →	+0.264	+3.584	<.001	.002	3	1
UCEC	ATM →	-0.545	-3.584	.012	.002	3	1
UCEC	4E-BP1_pS65 →	-0.193	-2.446	.041	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.891	+2.189	.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR by GPR22 expression — UCEC

Explore this box plot interactively →