Across TCGA cell cohorts, GPR21 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR21-associated genes across cancer lineages are COX6A2, FCN2, and SCGB3A2. Each is linked with GPR21 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR21-to-partner and partner-to-GPR21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR21→partner) and Y-score (partner→GPR21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COX6A2 →	+0.102	+5.022	<.001	.002	3	1
LARGE_INTESTINE	FCN2 →	+0.039	+4.415	<.001	.007	3	1
LARGE_INTESTINE	SCGB3A2 →	+0.365	+4.095	.001	.009	3	1
LARGE_INTESTINE	OR2K2 →	+0.026	+4.095	.003	.009	3	1
LARGE_INTESTINE	OR10C1 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR8S1 →	+0.031	+4.095	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

GPR21 survival (RNA) · tumor vs normal (RNA) · all GPR21 data types