Across TCGA patient cohorts, GPR19 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR19-associated genes across cancer lineages are Caspase-8, JNK_pT183_Y185, and MEK1. Each is linked with GPR19 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR19-to-partner and partner-to-GPR19 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR19→partner) and Y-score (partner→GPR19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.281	-3.673	.006	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.172	-1.794	.013	.027	3	1
UCEC	MEK1 →	+0.426	+3.584	.004	.002	3	1
UCEC	p62 Lck ligand →	+0.468	+3.459	<.001	.005	3	1
UCEC	PCNA →	+0.218	+3.169	.014	.018	3	1
UCEC	STAT3_pY705 →	-0.422	-1.990	<.001	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

GPR19 survival (RNA) · tumor vs normal (RNA) · all GPR19 data types