GPR183

Across TCGA patient cohorts, GPR183 mutation is significantly associated with the RNA expression of many other genes, with 460 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR183-associated genes across cancer lineages are MATK, MED28P4, and SLCO1B3. Each is linked with GPR183 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR183-to-partner and partner-to-GPR183 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MATK grouped by GPR183-low versus GPR183-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR183→partner) and Y-score (partner→GPR183) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MATK →	+0.560	+3.353	.007	.005	3	2
COAD	MED28P4 →	+0.183	+4.037	<.001	.004	3	2
UCEC	SLCO1B3 →	+0.775	+2.870	<.001	.004	3	2
UCEC	SNORD3B-2 →	+0.716	+2.818	<.001	.001	3	2
LUAD	RNA5SP405 →	+0.308	+7.930	<.001	.008	3	1
LUAD	SNORD115-3 →	+0.401	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 460 associations by consensus.

MATK by GPR183 expression — UCEC

Explore this box plot interactively →