GPR183

Across TCGA cell cohorts, GPR183 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,403 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR183-associated GO terms across cancer lineages are Negative regulation of ERBB signaling pathway, Regulation of T-helper 17 type immune response, and Negative regulation of pre-miRNA processing. Each is linked with GPR183 in more than 5 cancer types. Because this analysis shows association rather than direction, both GPR183-to-partner and partner-to-GPR183 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of ERBB signaling pathway grouped by GPR183-low versus GPR183-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR183→partner) and Y-score (partner→GPR183) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of ERBB signaling pathway →	+0.068	+0.068	.001	.004	2	6
BREAST	Regulation of T-helper 17 type immune response →	+0.079	+0.103	.004	.003	3	5
BREAST	Negative regulation of pre-miRNA processing →	-0.918	-0.105	.003	.003	3	5
BREAST	Actomyosin contractile ring assembly actin filament organization →	+0.205	+0.106	<.001	.004	3	5
BLOOD_Leukemia	Regulation of somatic stem cell population maintenance →	-0.081	-1.941	<.001	<.001	3	5
BLOOD_Leukemia	Positive regulation of translational initiation in response to stress →	+0.114	+2.993	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,403 associations by consensus.

Negative regulation of ERBB signaling pathway by GPR183 expression — URINARY_TRACT

Explore this box plot interactively →