GPR182

Across TCGA patient cohorts, GPR182 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR182-associated genes across cancer lineages are ERK2, MEK1, and JNK2. Each is linked with GPR182 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR182-to-partner and partner-to-GPR182 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by GPR182-low versus GPR182-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR182→partner) and Y-score (partner→GPR182) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.245	+3.169	.006	.019	3	2
UCEC	MEK1 →	+0.398	+2.999	.019	.035	3	2
UCEC	JNK2 →	+0.269	+2.584	.003	.011	2	2
UCEC	VHL →	-1.127	-3.321	<.001	.010	3	1
UCEC	Chk1 →	-0.163	-2.970	.035	.036	3	1
UCEC	eEF2K →	+0.351	+1.887	.030	.031	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ERK2 by GPR182 expression — UCEC

Explore this box plot interactively →