GPR182

Across TCGA cell cohorts, GPR182 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR182-associated genes across cancer lineages are PRAMEF20, MMP27, and OR2C3. Each is linked with GPR182 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR182-to-partner and partner-to-GPR182 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF20 grouped by GPR182-low versus GPR182-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR182→partner) and Y-score (partner→GPR182) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRAMEF20 →	+0.023	+5.662	<.001	.002	3	2
LUNG_NSCLC_LUAD	MMP27 →	+0.018	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR2C3 →	+0.818	+4.887	<.001	.009	3	1
LARGE_INTESTINE	IRX4 →	+0.533	+3.409	<.001	.009	3	1
LARGE_INTESTINE	MAGEA9 →	+0.239	+2.933	<.001	.003	3	1
LARGE_INTESTINE	RSPO3 →	+0.068	+3.176	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PRAMEF20 by GPR182 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →