GPR180

Across TCGA pan-cancer cohorts, GPR180 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of GPR180’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GPR180 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GPR180 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

HNSC, CCRCC, and LUAD are the cancer types where GPR180 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR180 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.885	<.001	12	view →
CCRCC	Female	II,III,IV	+0.647	<.001	12	view →
LUAD	Male	III,IV	+0.893	<.001	9	view →
LSCC	Female	All	+0.848	<.001	9	view →
PDAC	Male	All	−1.041	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

GPR180–HNSC

Open the HNSC breakdown →