GPR180

Across TCGA patient cohorts, GPR180 mutation is significantly associated with the RNA expression of many other genes, with 1,229 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR180-associated genes across cancer lineages are RNU6-222P, OR4K15, and PPP2R2B-IT1. Each is linked with GPR180 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR180-to-partner and partner-to-GPR180 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-222P grouped by GPR180-low versus GPR180-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR180→partner) and Y-score (partner→GPR180) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-222P →	+0.342	+2.376	.003	.007	3	2
UCEC	OR4K15 →	+0.042	+3.063	.001	.007	3	2
BLCA	PPP2R2B-IT1 →	+0.069	+7.640	<.001	.009	3	1
UCEC	CWC25 →	+0.542	+3.375	.001	.004	3	1
UCEC	TAF9 →	+0.703	+3.700	<.001	.001	3	1
UCEC	MIR6859-2 →	+0.412	+2.690	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,229 associations by consensus.

RNU6-222P by GPR180 expression — UCEC

Explore this box plot interactively →