GPR180

Across TCGA cell cohorts, GPR180 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,664 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR180-associated GO terms across cancer lineages are Ribosomal protein import into nucleus, Nucleotide-excision repair, DNA gap filling, and Centrosome duplication. Each is linked with GPR180 in more than 17 cancer types. Because this analysis shows association rather than direction, both GPR180-to-partner and partner-to-GPR180 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosomal protein import into nucleus grouped by GPR180-low versus GPR180-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR180→partner) and Y-score (partner→GPR180) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Ribosomal protein import into nucleus →	+0.147	+1.002	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Nucleotide-excision repair, DNA gap filling →	+0.095	+0.823	.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Centrosome duplication →	+0.105	+0.859	<.001	<.001	3	11
OESOPHAGUS	Protein localization to condensed chromosome →	+0.168	+0.714	.002	.004	2	12
UPPER_AERODIGESTIVE_TRACT	Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.110	+0.799	.001	.001	3	11
LARGE_INTESTINE	Protein localization to centrosome →	+0.064	+0.586	.004	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,664 associations by consensus.

Ribosomal protein import into nucleus by GPR180 expression — OESOPHAGUS

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