GPR18

Across TCGA patient cohorts, GPR18 protein abundance is significantly associated with the RNA expression of many other genes, with 588 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible GPR18-associated genes across cancer lineages are RBFOX2, RNF24, and PLS3. Each is linked with GPR18 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR18-to-partner and partner-to-GPR18 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPR18 versus RBFOX2 in PDAC, with a Pearson correlation of 0.97.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR18→partner) and Y-score (partner→GPR18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RBFOX2 →	+0.685	+1.988	<.001	.008	2	1
PDAC	RNF24 →	+0.423	+1.988	.005	.008	2	1
PDAC	PLS3 →	+0.818	+1.988	.005	.008	2	1
PDAC	KATNAL1 →	+0.893	+1.988	.007	.008	2	1
PDAC	SLC6A2 →	+0.430	+1.988	.001	.008	2	1
PDAC	MTMR9 →	+0.811	+1.988	.004	.008	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 588 associations by consensus.

GPR18 vs RBFOX2 — PDAC

Explore this scatter interactively →