GPR18

Across TCGA cell cohorts, GPR18 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,252 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR18-associated GO terms across cancer lineages are Regulation of double-strand break repair via homologous recombination, Late viral transcription, and Positive regulation of DNA recombination. Each is linked with GPR18 in more than 6 cancer types. Because this analysis shows association rather than direction, both GPR18-to-partner and partner-to-GPR18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair via homologous recombination grouped by GPR18-low versus GPR18-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR18→partner) and Y-score (partner→GPR18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of double-strand break repair via homologous recombination →	+0.082	+0.102	<.001	.001	3	7
UPPER_AERODIGESTIVE_TRACT	Late viral transcription →	+0.149	+0.111	<.001	<.001	3	7
OESOPHAGUS	Positive regulation of DNA recombination →	+0.061	+0.091	<.001	<.001	3	7
OESOPHAGUS	Positive regulation of double-strand break repair →	+0.079	+0.093	<.001	<.001	3	6
OESOPHAGUS	Epigenetic regulation of gene expression →	+0.048	+0.094	<.001	.003	3	6
OESOPHAGUS	Double-strand break repair via classical nonhomologous end joining →	+0.062	+0.066	.004	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,252 associations by consensus.

Regulation of double-strand break repair via homologous recombination by GPR18 expression — OESOPHAGUS

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