GPR18

Across TCGA cell cohorts, GPR18 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR18-associated genes across cancer lineages are TGM6, GSG1L2, and UBE2QL1. Each is linked with GPR18 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR18-to-partner and partner-to-GPR18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGM6 grouped by GPR18-low versus GPR18-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR18→partner) and Y-score (partner→GPR18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TGM6 →	+0.030	+6.569	<.001	<.001	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	UBE2QL1 →	+0.243	+3.722	<.001	.007	3	1
LARGE_INTESTINE	CHAT →	+0.022	+3.103	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TGM6 by GPR18 expression — BLOOD_Leukemia

Explore this box plot interactively →