Across TCGA patient cohorts, GPR173 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR173-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and 14-3-3_beta. Each is linked with GPR173 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR173-to-partner and partner-to-GPR173 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR173→partner) and Y-score (partner→GPR173) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.145	+2.999	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.332	+3.584	<.001	.002	3	2
UCEC	14-3-3_beta →	-0.077	-1.847	.036	.049	3	1
UCEC	eEF2 →	+0.400	+3.321	.002	.009	3	1
UCEC	EGFR_pY1068 →	-0.257	-1.847	.005	.008	3	1
UCEC	eIF4E →	+0.172	+1.847	.026	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

GPR173 survival (RNA) · tumor vs normal (RNA) · all GPR173 data types