GPR171

Across TCGA patient cohorts, GPR171 mutation is significantly associated with the RNA expression of many other genes, with 1,079 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR171-associated genes across cancer lineages are SEC13, C1orf50, and PLK1. Each is linked with GPR171 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR171-to-partner and partner-to-GPR171 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC13 grouped by GPR171-low versus GPR171-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR171→partner) and Y-score (partner→GPR171) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC13 →	+0.416	+2.625	.001	.005	3	2
UCEC	C1orf50 →	+0.310	+3.353	.004	.005	3	2
UCEC	PLK1 →	+0.802	+3.087	.001	<.001	3	2
UCEC	CHAF1A →	+0.773	+3.108	<.001	<.001	3	2
SKCM	DTYMK →	+0.569	+2.719	.002	.003	3	2
UCEC	PUSL1 →	+0.625	+2.807	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,079 associations by consensus.

SEC13 by GPR171 expression — UCEC

Explore this box plot interactively →