GPR171

Across TCGA patient cohorts, GPR171 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR171-associated genes across cancer lineages are INPP4B, eIF4E, and Shc_pY317. Each is linked with GPR171 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR171-to-partner and partner-to-GPR171 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by GPR171-low versus GPR171-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR171→partner) and Y-score (partner→GPR171) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.338	-2.102	.016	.019	3	2
SKCM	eIF4E →	+0.229	+3.000	.024	.036	3	1
SKCM	Shc_pY317 →	-0.248	-2.982	.022	.036	3	1
SKCM	Src →	-0.451	-3.000	<.001	.035	3	1
UCEC	ACVRL1 →	-0.174	-3.571	.003	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.176	-3.169	.017	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

INPP4B by GPR171 expression — UCEC

Explore this box plot interactively →