GPR162

Across TCGA patient cohorts, GPR162 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR162-associated genes across cancer lineages are ATM, 4E-BP1, and GSK-3_pS9. Each is linked with GPR162 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR162-to-partner and partner-to-GPR162 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GPR162-low versus GPR162-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR162→partner) and Y-score (partner→GPR162) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.535	-3.459	.004	.005	3	2
UCEC	4E-BP1 →	+0.410	+3.489	<.001	.002	3	2
BLCA	GSK-3_pS9 →	+0.356	+2.820	.031	.035	3	1
UCEC	EGFR_pY1068 →	-0.228	-2.459	.027	.019	3	1
UCEC	eIF4G →	+0.262	+1.807	.040	.027	3	1
UCEC	ERK2 →	+0.191	+2.321	.016	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ATM by GPR162 expression — UCEC

Explore this box plot interactively →