GPR158

Across TCGA patient cohorts, GPR158 protein abundance is significantly associated with the RNA expression of many other genes, with 4,147 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GPR158-associated genes across cancer lineages are PRODH, GRK3, and SEZ6L. Each is linked with GPR158 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR158-to-partner and partner-to-GPR158 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPR158 versus PRODH in GBM, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR158→partner) and Y-score (partner→GPR158) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+0.781	+0.449	<.001	<.001	3	1
GBM	GRK3 →	+0.531	+0.548	<.001	<.001	3	1
GBM	SEZ6L →	+1.759	+0.439	.001	<.001	3	1
GBM	PIK3IP1 →	+0.408	+0.285	.009	.007	3	1
GBM	SOX10 →	+1.576	+0.511	<.001	<.001	3	1
GBM	SEPTIN3 →	+0.862	+0.552	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,147 associations by consensus.

GPR158 vs PRODH — GBM

Explore this scatter interactively →