GPR158

Across TCGA patient cohorts, GPR158 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR158-associated genes across cancer lineages are MIG-6, Cyclin-B1, and Caveolin-1. Each is linked with GPR158 in more than 4 cancer types. Because this analysis shows association rather than direction, both GPR158-to-partner and partner-to-GPR158 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by GPR158-low versus GPR158-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR158→partner) and Y-score (partner→GPR158) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIG-6 →	+0.177	+2.016	.004	.004	3	5
UCEC	Cyclin-B1 →	+0.535	+1.947	<.001	<.001	3	5
COAD	Caveolin-1 →	-0.554	-1.874	.021	.049	3	5
UCEC	4E-BP1 →	+0.368	+1.862	<.001	<.001	3	4
SKCM	PDK1_pS241 →	-0.095	-0.939	.026	.020	3	4
LUAD	EGFR_pY1068 →	-0.347	-2.321	.019	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

MIG-6 by GPR158 expression — LUAD

Explore this box plot interactively →