GPR158

Across TCGA cell cohorts, GPR158 mutation is significantly associated with the RNA expression of many other genes, with 729 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR158-associated genes across cancer lineages are OR52E2, ATF4, and LYG1. Each is linked with GPR158 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR158-to-partner and partner-to-GPR158 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52E2 grouped by GPR158-low versus GPR158-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR158→partner) and Y-score (partner→GPR158) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR52E2 →	+0.016	+4.029	<.001	.007	3	2
LUNG_NSCLC_LUAD	ATF4 →	-0.505	-3.285	.003	.006	3	2
BLOOD_Leukemia	LYG1 →	+0.755	+3.318	<.001	.005	3	2
BLOOD_Leukemia	KSR2 →	+0.263	+2.698	.001	.002	3	2
BLOOD_Leukemia	TSSK1B →	+0.006	+2.704	<.001	.005	3	2
BLOOD_Leukemia	TAS2R39 →	+0.032	+2.924	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 729 associations by consensus.

OR52E2 by GPR158 expression — PANCREAS

Explore this box plot interactively →