GPR153

Across TCGA patient cohorts, GPR153 mutation is significantly associated with the RNA expression of many other genes, with 377 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR153-associated genes across cancer lineages are LINC02297, MIR4441, and RN7SL736P. Each is linked with GPR153 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR153-to-partner and partner-to-GPR153 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02297 grouped by GPR153-low versus GPR153-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR153→partner) and Y-score (partner→GPR153) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC02297 →	+0.076	+5.251	<.001	.006	3	2
SKCM	MIR4441 →	+0.243	+5.163	<.001	.002	3	2
SKCM	RN7SL736P →	+0.245	+3.333	<.001	.004	3	1
SKCM	MIR6074 →	+0.259	+4.897	<.001	.002	3	1
SKCM	DDX6P2 →	+0.037	+3.123	.004	.007	3	1
UCEC	IGHV3OR16-8 →	+0.898	+2.650	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 377 associations by consensus.

LINC02297 by GPR153 expression — BLCA

Explore this box plot interactively →