GPR153

Across TCGA patient cohorts, GPR153 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR153-associated genes across cancer lineages are ACC1, IRS1, and Lck. Each is linked with GPR153 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR153-to-partner and partner-to-GPR153 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by GPR153-low versus GPR153-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR153→partner) and Y-score (partner→GPR153) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.341	+2.115	.031	.019	3	1
UCEC	IRS1 →	-0.259	-3.321	.004	.010	3	1
UCEC	Lck →	+0.281	+2.115	.001	.019	3	1
UCEC	Akt_pS473 →	+0.724	+2.321	.020	.034	3	1
UCEC	Akt_pT308 →	+0.717	+3.169	.009	.018	3	1
UCEC	Annexin-1 →	+0.509	+2.341	.027	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ACC1 by GPR153 expression — UCEC

Explore this box plot interactively →