GPR153

Across TCGA cell cohorts, GPR153 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR153-associated genes across cancer lineages are CENPVL1, KRTAP4-2, and VAX1. Each is linked with GPR153 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR153-to-partner and partner-to-GPR153 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPVL1 grouped by GPR153-low versus GPR153-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR153→partner) and Y-score (partner→GPR153) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CENPVL1 →	+0.140	+4.129	.001	.007	3	2
OVARY	KRTAP4-2 →	+0.028	+5.196	<.001	.005	3	1
LARGE_INTESTINE	VAX1 →	+0.689	+3.519	<.001	.007	3	1
LARGE_INTESTINE	OR4F21 →	+0.158	+2.878	<.001	.009	3	1
LARGE_INTESTINE	FAM153B →	+0.506	+3.426	<.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

CENPVL1 by GPR153 expression — STOMACH

Explore this box plot interactively →