GPR151

Across TCGA patient cohorts, GPR151 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR151-associated genes across cancer lineages are INPP4B, Ku80, and Notch1. Each is linked with GPR151 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR151-to-partner and partner-to-GPR151 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by GPR151-low versus GPR151-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR151→partner) and Y-score (partner→GPR151) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.314	-3.169	.044	.019	3	1
UCEC	Ku80 →	+0.321	+3.013	.004	.018	3	1
UCEC	Notch1 →	+0.150	+2.820	.027	.035	3	1
UCEC	Akt_pT308 →	+0.727	+2.459	.016	.020	3	1
UCEC	STAT3_pY705 →	-0.535	-3.584	<.001	.002	3	1
UCEC	Tuberin_pT1462 →	+0.363	+2.331	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

INPP4B by GPR151 expression — UCEC

Explore this box plot interactively →