GPR151

Across TCGA cell cohorts, GPR151 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR151-associated genes across cancer lineages are HCRTR2, OR11H6, and TMEM215. Each is linked with GPR151 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR151-to-partner and partner-to-GPR151 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HCRTR2 grouped by GPR151-low versus GPR151-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR151→partner) and Y-score (partner→GPR151) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HCRTR2 →	+0.016	+4.966	<.001	<.001	3	1
BLOOD_Leukemia	OR11H6 →	+0.022	+3.705	.001	.007	3	1
BLOOD_Leukemia	TMEM215 →	+0.051	+4.234	<.001	.003	3	1
BLOOD_Leukemia	OR10R2 →	+1.499	+3.551	<.001	.009	3	1
BLOOD_Leukemia	LRRC3C →	+0.114	+3.796	<.001	.008	3	1
BLOOD_Leukemia	PRB1 →	+0.021	+3.551	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

HCRTR2 by GPR151 expression — BLOOD_Leukemia

Explore this box plot interactively →