GPR150

Across TCGA pan-cancer cohorts, GPR150 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GPR150’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GPR150 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPR150 is over-expressed in tumor, although a few such as BRCA and PRAD show the opposite, repressed pattern.

THCA, KIRC, and HNSC are the cancer types where GPR150 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR150 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	+0.326	<.001	11	view →
KIRC	Male	II,III,IV	+0.449	<.001	9	view →
HNSC	Male	All	+0.321	<.001	9	view →
KICH	All	All	+0.830	.001	6	view →
KIRP	Male	All	+0.521	<.001	6	view →
STAD	Male	III,IV	+0.403	.004	5	view →
LIHC	All	All	+0.300	<.001	5	view →
BLCA	Male	All	+0.792	.011	4	view →
BRCA	All	All	−0.129	.003	4	view →
PRAD	All	All	−0.349	<.001	2	view →
COAD	Male	II,III,IV	+0.339	.028	2	view →
ESCA	All	All	−0.842	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GPR150–THCA

Open the THCA breakdown →