GPR15

Across TCGA patient cohorts, GPR15 mutation is significantly associated with the RNA expression of many other genes, with 521 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR15-associated genes across cancer lineages are HADHBP1, NDUFA5P5, and RNU6-896P. Each is linked with GPR15 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR15-to-partner and partner-to-GPR15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HADHBP1 grouped by GPR15-low versus GPR15-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR15→partner) and Y-score (partner→GPR15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HADHBP1 →	+0.112	+3.589	<.001	.004	3	2
LUAD	NDUFA5P5 →	+0.115	+4.122	<.001	.009	3	2
BRCA	RNU6-896P →	+0.296	+7.731	<.001	.009	3	2
BRCA	RNA5SP222 →	+0.286	+7.731	<.001	.009	3	2
COAD	BPY2DP →	+0.157	+5.409	<.001	.001	3	2
COAD	RN7SL83P →	+0.366	+4.392	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 521 associations by consensus.

HADHBP1 by GPR15 expression — SKCM

Explore this box plot interactively →