GPR15

Across TCGA patient cohorts, GPR15 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR15-associated genes across cancer lineages are MEK1, EGFR_pY1173, and Rab25. Each is linked with GPR15 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR15-to-partner and partner-to-GPR15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by GPR15-low versus GPR15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR15→partner) and Y-score (partner→GPR15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.465	+3.584	.008	.002	3	2
UCEC	EGFR_pY1173 →	-0.118	-2.979	.002	.036	3	1
UCEC	Rab25 →	-0.552	-2.999	<.001	.035	3	1
UCEC	Annexin-1 →	+0.704	+3.189	.005	.010	3	1
UCEC	AR →	-0.451	-2.459	.012	.020	3	1
UCEC	4E-BP1 →	+0.319	+3.029	.014	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MEK1 by GPR15 expression — UCEC

Explore this box plot interactively →