GPR146

Across TCGA pan-cancer cohorts, GPR146 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GPR146 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher GPR146 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPR146 expression acts as an unfavorable survival marker.

LGG, UCEC, and COAD are the cancer types where GPR146 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.110	0.833	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	DFS	Median	All	0.515	0.795	.013	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GPR146–LGG (DFS)

Open the LGG breakdown →