GPR146

Across TCGA patient cohorts, GPR146 mutation is significantly associated with the RNA expression of many other genes, with 628 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR146-associated genes across cancer lineages are MIR4535, IGSF22, and C9orf50. Each is linked with GPR146 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR146-to-partner and partner-to-GPR146 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4535 grouped by GPR146-low versus GPR146-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR146→partner) and Y-score (partner→GPR146) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MIR4535 →	+0.901	+5.187	<.001	.007	3	2
UCEC	IGSF22 →	-0.304	-2.960	.004	.001	3	1
UCEC	C9orf50 →	-0.528	-3.791	.001	<.001	3	1
UCEC	CCDC89 →	-0.764	-3.247	.001	<.001	3	1
UCEC	TMEM31 →	-0.596	-2.531	.005	.001	3	1
UCEC	VWA1 →	-0.765	-3.563	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 628 associations by consensus.

MIR4535 by GPR146 expression — STAD

Explore this box plot interactively →