GPR146

Across TCGA patient cohorts, GPR146 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR146-associated genes across cancer lineages are eEF2, EGFR_pY1068, and ERK2. Each is linked with GPR146 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR146-to-partner and partner-to-GPR146 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GPR146-low versus GPR146-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR146→partner) and Y-score (partner→GPR146) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.345	+2.321	.019	.033	3	1
UCEC	EGFR_pY1068 →	-0.341	-2.321	<.001	.006	3	1
UCEC	ERK2 →	+0.181	+3.169	.022	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.181	-2.990	<.001	<.001	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.565	+3.469	.007	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.246	-3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eEF2 by GPR146 expression — UCEC

Explore this box plot interactively →