GPR146

Across TCGA cell cohorts, GPR146 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,834 significant associations in total. CNS shows the largest number of these associations.

The most reproducible GPR146-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Regulation of metaphase plate congression, and Regulation of G1/S transition of mitotic cell cycle. Each is linked with GPR146 in more than 12 cancer types. Because this analysis shows association rather than direction, both GPR146-to-partner and partner-to-GPR146 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by GPR146-low versus GPR146-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR146→partner) and Y-score (partner→GPR146) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of calcium ion export across plasma membrane →	+0.092	+0.730	<.001	.003	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase plate congression →	+0.118	+0.794	.007	.001	2	13
STOMACH	Regulation of G1/S transition of mitotic cell cycle →	+0.102	+1.236	<.001	<.001	3	12
BONE	Protein-containing complex disassembly →	+0.064	+1.039	<.001	.003	3	12
CNS	Positive regulation of cellular response to transforming growth factor beta stimulus →	+0.098	+1.121	<.001	<.001	3	11
BONE	Negative regulation of DNA-templated transcription initiation →	+0.160	+1.177	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,834 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by GPR146 expression — BREAST

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